"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
| Descriptor ID |
D005341
|
| MeSH Number(s) |
D08.811.277.656.300.760.330 D08.811.277.656.959.350.330
|
| Concept/Terms |
Fibrinolysin- Fibrinolysin
- Plasmin
- Protease F
- Glu-Plasmin
- Glu Plasmin
|
Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".
Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".
This graph shows the total number of publications written about "Fibrinolysin" by people in this website by year, and whether "Fibrinolysin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibrinolysin" by people in Profiles.
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Factor VIII: A Dynamic Modulator of Hemostasis and Thrombosis in Trauma. Anesth Analg. 2023 05 01; 136(5):894-904.
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A Pharmacokinetic and Plasmin-Generation Pharmacodynamic Assessment of a Tranexamic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2022 08; 36(8 Pt A):2473-2482.
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Excessive Plasmin Compromises Hepatic Sinusoidal Vascular Integrity After Acetaminophen Overdose. Hepatology. 2018 11; 68(5):1991-2003.
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CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 06 01; 126(6):2254-66.
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The NuRD chromatin-remodeling enzyme CHD4 promotes embryonic vascular integrity by transcriptionally regulating extracellular matrix proteolysis. PLoS Genet. 2013; 9(12):e1004031.
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Kinetics of activated thrombin-activatable fibrinolysis inhibitor (TAFIa)-catalyzed cleavage of C-terminal lysine residues of fibrin degradation products and removal of plasminogen-binding sites. J Biol Chem. 2011 Jun 03; 286(22):19280-6.
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Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Am J Pathol. 2007 Sep; 171(3):1066-77.
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A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion. Blood. 2004 May 15; 103(10):3783-8.
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Crosslinking of alpha 2-antiplasmin to fibrin. Ann N Y Acad Sci. 2001; 936:335-9.
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A rapid purification of streptokinase by affinity chromatography. Thromb Res. 1979 Feb-Mar; 14(2-3):405-11.