Anaphase-Promoting Complex-Cyclosome
"Anaphase-Promoting Complex-Cyclosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability.
| Descriptor ID |
D064173
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| MeSH Number(s) |
D08.811.464.938.750.092 D12.776.167.024
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Anaphase-Promoting Complex-Cyclosome".
Below are MeSH descriptors whose meaning is more specific than "Anaphase-Promoting Complex-Cyclosome".
- Anaphase-Promoting Complex-Cyclosome
- Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc4 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome
- Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
- Cdc20 Proteins
- Cdh1 Proteins
This graph shows the total number of publications written about "Anaphase-Promoting Complex-Cyclosome" by people in this website by year, and whether "Anaphase-Promoting Complex-Cyclosome" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
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Below are the most recent publications written about "Anaphase-Promoting Complex-Cyclosome" by people in Profiles.
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Casein kinase 1d is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis. Cell Rep. 2015 Apr 14; 11(2):249-60.
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Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol. 2015 Feb; 16(2):82-94.
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The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell. 2014 Mar; 25(5):594-605.
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Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation. Mol Cell Biol. 2012 Feb; 32(3):590-605.
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Sororin, the cell cycle and sister chromatid cohesion. Cell Cycle. 2005 Aug; 4(8):1039-42.
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Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 2005 Apr 15; 18(2):185-200.
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Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell. 2003 Apr 04; 113(1):101-13.
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Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells. J Cell Biol. 2002 Sep 02; 158(5):841-7.
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Elevating the level of Cdc34/Ubc3 ubiquitin-conjugating enzyme in mitosis inhibits association of CENP-E with kinetochores and blocks the metaphase alignment of chromosomes. J Cell Biol. 2001 Aug 20; 154(4):707-17.
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The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome. Curr Biol. 2000 Nov 30; 10(23):R850-2.