"Osteopontin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
| Descriptor ID |
D053495
|
| MeSH Number(s) |
D12.644.276.374.625 D12.776.395.700.837 D12.776.467.374.625 D12.776.860.300.762 D23.529.374.625
|
| Concept/Terms |
Osteopontin- Osteopontin
- Sialoprotein 1
- Secreted Phosphoprotein 1
- Bone Sialoprotein 1
- Sialoprotein 1, Bone
- Bone Sialoprotein I
- Sialoprotein I, Bone
|
Below are MeSH descriptors whose meaning is more general than "Osteopontin".
Below are MeSH descriptors whose meaning is more specific than "Osteopontin".
This graph shows the total number of publications written about "Osteopontin" by people in this website by year, and whether "Osteopontin" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Osteopontin" by people in Profiles.
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Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1+ monocytes-derived macrophages. Ann Rheum Dis. 2025 Feb; 84(2):294-306.
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Osteopontin deletion attenuates cyst growth but exacerbates fibrosis in mice with cystic kidney disease. Physiol Rep. 2024 Sep; 12(17):e70038.
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Osteopontin contributes to virus resistance associated with type I IFN expression, activation of downstream ifn-inducible effector genes, and CCR2+CD115+CD206+ macrophage infiltration following ocular HSV-1 infection of mice. Front Immunol. 2022; 13:1028341.
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Loss of Osteopontin Expression Reduces HSV-1-Induced Corneal Opacity. Invest Ophthalmol Vis Sci. 2020 08 03; 61(10):24.
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Osteopontin and Disease Activity in Patients with Recent-onset Systemic Lupus Erythematosus: Results from the SLICC Inception Cohort. J Rheumatol. 2019 05; 46(5):492-500.
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Osteopontin-targeted probe detects orthotopic breast cancers using optoacoustic imaging. Biotech Histochem. 2018; 93(8):608-614.
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Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction. PLoS One. 2008 Mar 12; 3(3):e0001757.
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In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2488-93.
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Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis. Toxicol Appl Pharmacol. 2005 Aug 22; 207(1):25-38.
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Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12600-5.