"Didanosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
| Descriptor ID |
D016049
|
| MeSH Number(s) |
D03.633.100.759.590.616.130 D13.570.230.500.090 D13.570.583.616.130 D13.570.800.573.130
|
| Concept/Terms |
Didanosine- Didanosine
- Dideoxyinosine
- 2',3'-Dideoxyinosine
- 2',3' Dideoxyinosine
- ddI (Antiviral)
|
Below are MeSH descriptors whose meaning is more general than "Didanosine".
Below are MeSH descriptors whose meaning is more specific than "Didanosine".
This graph shows the total number of publications written about "Didanosine" by people in this website by year, and whether "Didanosine" was a major or minor topic of these publications.
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Below are the most recent publications written about "Didanosine" by people in Profiles.
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Nevirapine, didanosine, and zidovudine for patients with HIV: the INCAS trial. Italy, Netherlands, Canada, and Australia. JAMA. 1999 Jan 13; 281(2):130; author reply 131.
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Physiologically based pharmacokinetic models of 2',3'-dideoxyinosine. Pharm Res. 1997 Mar; 14(3):337-44.
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Pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and pentamidine in rats. Pharm Res. 1996 Apr; 13(4):628-32.
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Extensive absorption of 2',3'-dideoxyinosine by intratracheal administration in rats. Pharm Res. 1995 Dec; 12(12):1901-6.
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Use of drug kinetics in dermis to predict in vivo blood concentration after topical application. Pharm Res. 1995 Dec; 12(12):2012-7.
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Penetration kinetics of 2',3'-dideoxyinosine in dermis is described by the distributed model. Pharm Res. 1995 Jan; 12(1):108-12.
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Tissue pharmacokinetics of 2',3'-dideoxyinosine in rats. Biochem Pharmacol. 1994 Nov 29; 48(11):2109-16.
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Differential antiviral activities and intracellular metabolism of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine in human cells. Antimicrob Agents Chemother. 1994 Jul; 38(7):1573-9.
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Percutaneous absorption of 2',3'-dideoxyinosine in rats. Pharm Res. 1994 Jun; 11(6):809-15.
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Absorption of 2',3'-dideoxyinosine from lower gastrointestinal tract in rats and kinetic evidence of different absorption rates in colon and rectum. Pharm Res. 1993 May; 10(5):763-70.