William Sonntag to Insulin-Like Growth Factor I
This is a "connection" page, showing publications William Sonntag has written about Insulin-Like Growth Factor I.
Connection Strength
9.257
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IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan. Geroscience. 2017 04; 39(2):129-145.
Score: 0.472
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Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice. Age (Dordr). 2016 Apr; 38(2):38.
Score: 0.437
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IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. J Bone Miner Res. 2016 Feb; 31(2):443-54.
Score: 0.422
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Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol. 2015 Aug; 68:76-81.
Score: 0.396
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Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1353-62.
Score: 0.392
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Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):587-98.
Score: 0.334
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Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence. J Endocrinol. 2011 Oct; 211(1):27-37.
Score: 0.317
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Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression. Neuroscience. 2011 Jun 30; 185:50-60.
Score: 0.312
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Growth hormone and IGF-I modulate local cerebral glucose utilization and ATP levels in a model of adult-onset growth hormone deficiency. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E604-10.
Score: 0.221
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Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev. 2005 May; 4(2):195-212.
Score: 0.206
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Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span. Endocrinology. 2005 Jul; 146(7):2920-32.
Score: 0.205
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Of worms, flies, dwarfs, and things that go bump in the night. Sci Aging Knowledge Environ. 2002 Oct 30; 2002(43):pe17.
Score: 0.173
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A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet. 2002 Jun; 18(6):295-301.
Score: 0.168
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Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination. J Gerontol A Biol Sci Med Sci. 2002 May; 57(5):B177-88.
Score: 0.167
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Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system. Cardiovasc Res. 2002 Apr; 54(1):25-35.
Score: 0.166
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Insulin-like growth factor-1 selectively increases glucose utilization in brains of aged animals. Endocrinology. 2001 Jan; 142(1):506-9.
Score: 0.153
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The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J Anat. 2000 Nov; 197 Pt 4:575-85.
Score: 0.151
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Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum. 2000 Sep; 43(9):2110-20.
Score: 0.149
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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats. Brain Res Bull. 2000 Mar 01; 51(4):331-8.
Score: 0.144
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Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J Gerontol A Biol Sci Med Sci. 1999 Dec; 54(12):B521-38.
Score: 0.142
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Central IGF-1 protects against features of cognitive and sensorimotor decline with aging in male mice. Geroscience. 2019 04; 41(2):185-208.
Score: 0.136
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Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. Neuroscience. 1999 Jan; 88(1):269-79.
Score: 0.133
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Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience. 1998 Dec; 87(3):559-69.
Score: 0.132
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Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway x Fischer 344 rat brain. Brain Res. 1998 Aug 31; 804(1):79-86.
Score: 0.130
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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-ß uptake in astrocytes. Mol Metab. 2018 03; 9:141-155.
Score: 0.125
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Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1. Endocrinology. 1997 Aug; 138(8):3515-20.
Score: 0.120
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Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell. 2017 06; 16(3):469-479.
Score: 0.117
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The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer. Geroscience. 2017 04; 39(2):147-160.
Score: 0.117
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Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr). 2016 Aug; 38(4):273-289.
Score: 0.113
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IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr). 2016 Aug; 38(4):239-258.
Score: 0.113
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Effects of age and insulin-like growth factor-1 on rat neurotrophin receptor expression after nerve injury. Muscle Nerve. 2016 10; 54(4):769-75.
Score: 0.112
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Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age. Endocrinology. 1995 Oct; 136(10):4551-7.
Score: 0.106
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Ethanol suppresses growth hormone-mediated cellular responses in liver slices. Alcohol Clin Exp Res. 1995 Oct; 19(5):1246-51.
Score: 0.106
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Effect of ethanol on plasma and hepatic insulin-like growth factor regulation in pregnant rats. Alcohol Clin Exp Res. 1995 Aug; 19(4):867-73.
Score: 0.105
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IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging. Aging Cell. 2015 Dec; 14(6):1034-44.
Score: 0.104
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Insulin-like growth factor-1 stimulation of protein synthesis is attenuated in cerebral cortex of aging rats. Neuroscience. 1995 Apr; 65(3):805-13.
Score: 0.102
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Effect of in utero ethanol exposure on the postnatal ontogeny of insulin-like growth factor-1, and type-1 and type-2 insulin-like growth factor receptors in the rat brain. Neuroscience. 1994 Nov; 63(2):579-89.
Score: 0.100
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IGF-1 deficiency impairs cerebral myogenic autoregulation in hypertensive mice. J Cereb Blood Flow Metab. 2014 Dec; 34(12):1887-97.
Score: 0.099
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Long-term suppression of insulin-like growth factor-1 in rats after in utero ethanol exposure: relationship to somatic growth. J Pharmacol Exp Ther. 1993 Jan; 264(1):448-56.
Score: 0.088
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The regulation and mechanisms of action of growth hormone and insulin-like growth factor 1 during normal ageing. J Reprod Fertil Suppl. 1993; 46:87-98.
Score: 0.088
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Effects of aging and dietary restriction on tissue protein synthesis: relationship to plasma insulin-like growth factor-1. J Gerontol. 1992 Sep; 47(5):B159-63.
Score: 0.086
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Aging, synaptic dysfunction, and insulin-like growth factor (IGF)-1. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):611-25.
Score: 0.083
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Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(6):553-64.
Score: 0.081
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Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging. J Gerontol A Biol Sci Med Sci. 2012 Apr; 67(4):313-29.
Score: 0.081
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Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J Gerontol. 1991 Sep; 46(5):B180-7.
Score: 0.080
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Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm IGF Res. 2011 Apr; 21(2):81-8.
Score: 0.077
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Distribution of insulin-like growth factor 1 (IGF-1) and 2 (IGF-2) receptors in the hippocampal formation of rats and mice. Adv Exp Med Biol. 1991; 293:449-58.
Score: 0.076
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Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats. Muscle Nerve. 2010 Mar; 41(3):335-41.
Score: 0.072
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Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J Endocrinol. 2010 Jan; 204(1):31-6.
Score: 0.070
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I alters oligodendrocyte turnover in the corpus callosum. Glia. 2009 Aug 01; 57(10):1062-71.
Score: 0.069
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The ependymal route for insulin-like growth factor-1 gene therapy in the brain. Neuroscience. 2009 Sep 29; 163(1):442-7.
Score: 0.069
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Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I. Growth Factors. 2009 Jun; 27(3):181-8.
Score: 0.068
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Diminished insulin-like growth factor-1 levels after chronic ethanol: relationship to pulsatile growth hormone release. Alcohol Clin Exp Res. 1989 Feb; 13(1):3-7.
Score: 0.067
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Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats. J Gerontol A Biol Sci Med Sci. 2008 Sep; 63(9):911-20.
Score: 0.065
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Chronic ethanol feeding inhibits plasma levels of insulin-like growth factor-1. Life Sci. 1988; 43(16):1325-30.
Score: 0.062
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Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. Arthritis Rheum. 2006 Dec; 54(12):3850-8.
Score: 0.057
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Adult-onset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: insights into the regulation of adult hippocampal neurogenesis. J Neurosci Res. 2006 Feb 01; 83(2):199-210.
Score: 0.054
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Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mech Ageing Dev. 2006 Jan; 127(1):57-63.
Score: 0.053
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Dendritic stability in a model of adult-onset IGF-I deficiency. Growth Horm IGF Res. 2005 Oct; 15(5):337-48.
Score: 0.053
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Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. J Neurophysiol. 2005 Jul; 94(1):247-54.
Score: 0.052
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Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cereb Cortex. 2005 May; 15(5):571-7.
Score: 0.049
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Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning. Neuroscience. 2004; 129(1):119-27.
Score: 0.047
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Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology. 2002 Oct; 143(10):4139-42.
Score: 0.043
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Insulin-like growth factor-1 does not ameliorate the age-related decline in presumptive inhibitory synapses in layer 2 of rat sensorimotor cortex. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jan; 26(1):97-102.
Score: 0.041
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Growth hormone increases regional coronary blood flow and capillary density in aged rats. J Gerontol A Biol Sci Med Sci. 2001 Aug; 56(8):B364-71.
Score: 0.040
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Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience. 2001; 107(4):603-13.
Score: 0.038
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Effects of age and insulin-like growth factor-1 on neuron and synapse numbers in area CA3 of hippocampus. Neuroscience. 2001; 107(2):231-8.
Score: 0.038
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Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. J Gerontol A Biol Sci Med Sci. 2000 Feb; 55(2):B106-12.
Score: 0.036
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Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. Neurobiol Aging. 2018 11; 71:1-12.
Score: 0.032
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L-type Ca2+ channel-insulin-like growth factor-1 receptor signaling impairment in aging rat skeletal muscle. Biochem Biophys Res Commun. 1997 Jun 27; 235(3):784-9.
Score: 0.030
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Expression of insulin-like growth factor-1 (IGF-1) and IGF-binding protein 2 (IGF-BP2) in the hippocampus following cytotoxic lesion of the dentate gyrus. J Comp Neurol. 1996 Jun 03; 369(3):388-404.
Score: 0.028
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Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction. J Gerontol A Biol Sci Med Sci. 1996 Mar; 51(2):B167-74.
Score: 0.027
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Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats. Mech Ageing Dev. 1993 Oct 01; 71(1-2):59-71.
Score: 0.023
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Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol Aging. 2012 Sep; 33(9):1938-49.
Score: 0.020
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Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats. J Gerontol A Biol Sci Med Sci. 2010 Nov; 65(11):1145-56.
Score: 0.019