Chen J, Ding Y, Jiang C, Qu R, Wren JD, Georgescu C, Wang X, Reuter DN, Liu B, Giles CB, Mayr CH, Schiller HB, Dai J, Stipp CS, Subramaniyan B, Wang J, Zuo H, Huang C, Fung KM, Rice HC, Sonnenberg A, Wu D, Walters MS, Zhao YY, Kanie T, Hays FA, Papin JF, Wang DW, Zhang XA
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation. Circ Res. 2024 Apr 01.
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation.
Carter CM, Mathias MM, Bailey-Downs L, Tipple TE, Vitiello PF, Walters MS, Ganguly A
Journal of visualized experiments : JoVE
Translational 3D-Cell Culture Model to Assess Hyperoxia Effects on Human Neonatal Airway Epithelial Cells. J Vis Exp. 2024 Jul 12; (209).
Translational 3D-Cell Culture Model to Assess Hyperoxia Effects on Human Neonatal Airway Epithelial Cells.
Office of the Vice President for Research
Subramaniyan B, Falcon EC, Moore AR, Larabee JL, Nimmo SL, Berrios-Rivera JL, Reddig WJ, Blewett EL, Papin JF, Walters MS, Burgett AWG
Anti-SARS-CoV-2 Small Molecule Targeting of Oxysterol-Binding Protein (OSBP) Activates Cellular Antiviral Innate Immunity. ACS Infect Dis. 2025 May 09; 11(5):1064-1077.
Anti-SARS-CoV-2 Small Molecule Targeting of Oxysterol-Binding Protein (OSBP) Activates Cellular Antiviral Innate Immunity.
Seibert B, Caceres CJ, Gay LC, Shetty N, Faccin FC, Carnaccini S, Walters MS, Marr LC, Lowen AC, Rajao DS, Perez DR
Air-liquid interface model for influenza aerosol exposure in vitro. J Virol. 2025 Jun 03; e0061925.
Air-liquid interface model for influenza aerosol exposure in vitro.
Notch regulation of airway epithelial-immune cell cross-talk in SARS-CoV-2 infection
Ding Y, Chen J, Liu S, Hays JM, Gu X, Wren JD, Georgescu C, Reuter DN, Liu B, He F, Wang X, Wei Q, Wang J, Subramaniyan B, Wu Z, Kodali K, Reagan AM, Freeman WM, Miranti CK, Csiszar A, Ungvari Z, Mehla K, Walters MS, Elliott MH, Peng J, Kanie T, Papin JF, Hays FA, Zhang XA
Publisher Correction: Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases. Nat Cardiovasc Res. 2025 Sep; 4(9):1207.
Publisher Correction: Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases.
Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases. Nat Cardiovasc Res. 2025 Aug; 4(8):1011-1033.
Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases.
Ganguly A, Carter CM, Negron AR, Zhong H, Moreira A, Walters MS, Rogers LK, Prakash YS, Tipple TE, Richardson A
bioRxiv : the preprint server for biology
Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells. bioRxiv. 2025 Jun 15.
Quantitative Proteomics Links Mitochondrial Dysfunction to Metabolic Changes and Epithelial Differentiation Defects in Hyperoxia-Exposed Neonatal Airway Cells.
Bodas M, Subramaniyan B, Moore AR, Metcalf JP, Ocañas SR, Freeman WM, Georgescu C, Wren JD, Walters MS
The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation. Cells. 2021 11 18; 10(11).
The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation.
Subramaniyan B, Larabee JL, Bodas M, Moore AR, Burgett AWG, Myers DA, Georgescu C, Wren JD, Papin JF, Walters MS
Characterization of the SARS-CoV-2 Host Response in Primary Human Airway Epithelial Cells from Aged Individuals. Viruses. 2021 08 12; 13(8).
Characterization of the SARS-CoV-2 Host Response in Primary Human Airway Epithelial Cells from Aged Individuals.
Ryan DM, Vincent TL, Salit J, Walters MS, Agosto-Perez F, Shaykhiev R, Strulovici-Barel Y, Downey RJ, Buro-Auriemma LJ, Staudt MR, Hackett NR, Mezey JG, Crystal RG
Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. PLoS One. 2014; 9(2):e88051.
Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2.
Staudt MR, Buro-Auriemma LJ, Walters MS, Salit J, Vincent T, Shaykhiev R, Mezey JG, Tilley AE, Kaner RJ, Ho MW, Crystal RG
American journal of respiratory and critical care medicine
Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):955-8.
Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease.
Tilley AE, Walters MS, Shaykhiev R, Crystal RG
Cilia dysfunction in lung disease. Annu Rev Physiol. 2015; 77:379-406.
Durgan J, Tao G, Walters MS, Florey O, Schmidt A, Arbelaez V, Rosen N, Crystal RG, Hall A
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1. EMBO Rep. 2015 Jan; 16(1):87-96.
SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.
Wang G, Zhou H, Strulovici-Barel Y, Al-Hijji M, Ou X, Salit J, Walters MS, Staudt MR, Kaner RJ, Crystal RG
Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium. Autophagy. 2017 Jul 03; 13(7):1205-1220.
Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium.
Zuo WL, Shenoy SA, Li S, O'Beirne SL, Strulovici-Barel Y, Leopold PL, Wang G, Staudt MR, Walters MS, Mason C, Kaner RJ, Mezey JG, Crystal RG
Ontogeny and Biology of Human Small Airway Epithelial Club Cells. Am J Respir Crit Care Med. 2018 12 01; 198(11):1375-1388.
Ontogeny and Biology of Human Small Airway Epithelial Club Cells.
Goodwin DJ, Walters MS, Smith PG, Thurau M, Fickenscher H, Whitehouse A
Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line. J Virol. 2001 Apr; 75(8):4008-13.
Herpesvirus saimiri open reading frame 50 (Rta) protein reactivates the lytic replication cycle in a persistently infected A549 cell line.
The herpesvirus saimiri Rta gene autostimulates via binding to a non-consensus response element. J Gen Virol. 2005 Mar; 86(Pt 3):581-587.
The herpesvirus saimiri Rta gene autostimulates via binding to a non-consensus response element.
The Herpesvirus saimiri replication and transcription activator acts synergistically with CCAAT enhancer binding protein alpha to activate the DNA polymerase promoter. J Virol. 2005 Nov; 79(21):13548-60.
The Herpesvirus saimiri replication and transcription activator acts synergistically with CCAAT enhancer binding protein alpha to activate the DNA polymerase promoter.
Hackett NR, Shaykhiev R, Walters MS, Wang R, Zwick RK, Ferris B, Witover B, Salit J, Crystal RG
The human airway epithelial basal cell transcriptome. PLoS One. 2011 May 04; 6(5):e18378.
The human airway epithelial basal cell transcriptome.
Curradi G, Walters MS, Ding BS, Rafii S, Hackett NR, Crystal RG
Cellular and molecular life sciences : CMLS
Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells. Cell Mol Life Sci. 2012 Jul; 69(13):2217-31.
Airway basal cell vascular endothelial growth factor-mediated cross-talk regulates endothelial cell-dependent growth support of human airway basal cells.
Gomi K, Staudt MR, Salit J, Kaner RJ, Heldrich J, Rogalski AM, Arbelaez V, Crystal RG, Walters MS
JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium. Stem Cell Rev Rep. 2016 Aug; 12(4):454-63.
JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium.
Walters MS, Salit J, Ju JH, Staudt MR, Kaner RJ, Rogalski AM, Sodeinde TB, Rahim R, Strulovici-Barel Y, Mezey JG, Almulla AM, Sattar H, Mahmoud M, Crystal RG
Waterpipe smoking induces epigenetic changes in the small airway epithelium. PLoS One. 2017; 12(3):e0171112.
Waterpipe smoking induces epigenetic changes in the small airway epithelium.
Bodas M, Moore AR, Subramaniyan B, Georgescu C, Wren JD, Freeman WM, Brown BR, Metcalf JP, Walters MS
American journal of respiratory cell and molecular biology
Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2021 04; 64(4):426-440.
Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells.
Walters MS, Kyratsous CA, Wan S, Silverstein S
Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner. J Virol. 2008 Sep; 82(17):8673-86.
Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner.
Kyratsous CA, Walters MS, Panagiotidis CA, Silverstein SJ
Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p. J Virol. 2009 Oct; 83(20):10637-43.
Complementation of a herpes simplex virus ICP0 null mutant by varicella-zoster virus ORF61p.
Mueller NH, Walters MS, Marcus RA, Graf LL, Prenni J, Gilden D, Silverstein SJ, Cohrs RJ
Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63. J Gen Virol. 2010 May; 91(Pt 5):1133-7.
Identification of phosphorylated residues on varicella-zoster virus immediate-early protein ORF63.
Walters MS, Kinchington PR, Banfield BW, Silverstein S
Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases. J Virol. 2010 Oct; 84(19):9666-76.
Hyperphosphorylation of histone deacetylase 2 by alphaherpesvirus US3 kinases.
Didon L, Zwick RK, Chao IW, Walters MS, Wang R, Hackett NR, Crystal RG
RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium. Respir Res. 2013 Jul 03; 14:70.
RFX3 modulation of FOXJ1 regulation of cilia genes in the human airway epithelium.
Buro-Auriemma LJ, Salit J, Hackett NR, Walters MS, Strulovici-Barel Y, Staudt MR, Fuller J, Mahmoud M, Stevenson CS, Hilton H, Ho MW, Crystal RG
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression. Hum Mol Genet. 2013 Dec 01; 22(23):4726-38.
Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression.
Walters MS, Gomi K, Ashbridge B, Moore MA, Arbelaez V, Heldrich J, Ding BS, Rafii S, Staudt MR, Crystal RG
Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity. Respir Res. 2013 Dec 03; 14:135.
Generation of a human airway epithelium derived basal cell line with multipotent differentiation capacity.
Feng B, Jiao P, Helou Y, Li Y, He Q, Walters MS, Salomon A, Xu H
Mitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity. Diabetes. 2014 Sep; 63(9):2924-34.
Mitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity.
Ding BS, Gomi K, Rafii S, Crystal RG, Walters MS
Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells. J Cell Sci. 2015 Aug 15; 128(16):2983-8.
Endothelial MMP14 is required for endothelial-dependent growth support of human airway basal cells.
Deeb RS, Walters MS, Strulovici-Barel Y, Chen Q, Gross SS, Crystal RG
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype. Am J Respir Cell Mol Biol. 2016 Feb; 54(2):231-40.
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype.
Zhou H, Brekman A, Zuo WL, Ou X, Shaykhiev R, Agosto-Perez FJ, Wang R, Walters MS, Salit J, Strulovici-Barel Y, Staudt MR, Kaner RJ, Mezey JG, Crystal RG, Wang G
Journal of immunology (Baltimore, Md. : 1950)
POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. J Immunol. 2016 Apr 01; 196(7):3159-67.
POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes.
Zhang H, Yang J, Walters MS, Staudt MR, Strulovici-Barel Y, Salit J, Mezey JG, Leopold PL, Crystal RG
Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration. Oncotarget. 2018 Mar 06; 9(18):14324-14337.
Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration.
Ogawa F, Walters MS, Shafquat A, O'Beirne SL, Kaner RJ, Mezey JG, Zhang H, Leopold PL, Crystal RG
Role of KRAS in regulating normal human airway basal cell differentiation. Respir Res. 2019 Aug 09; 20(1):181.
Role of KRAS in regulating normal human airway basal cell differentiation.
Wu W, Zhang W, Tian L, Brown BR, Walters MS, Metcalf JP
IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia. Viruses. 2020 03 29; 12(4).
IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia.
The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an at hook required for binding to the ORF 50 response element in delayed-early promoters. J Virol. 2004 May; 78(9):4936-42.
The herpesvirus saimiri open reading frame (ORF) 50 (Rta) protein contains an at hook required for binding to the ORF 50 response element in delayed-early promoters.
Walters MS, Erazo A, Kinchington PR, Silverstein S
Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection. J Virol. 2009 Nov; 83(22):11502-13.
Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection.
Walters MS, Kyratsous CA, Silverstein SJ
The RING finger domain of Varicella-Zoster virus ORF61p has E3 ubiquitin ligase activity that is essential for efficient autoubiquitination and dispersion of Sp100-containing nuclear bodies. J Virol. 2010 Jul; 84(13):6861-5.
The RING finger domain of Varicella-Zoster virus ORF61p has E3 ubiquitin ligase activity that is essential for efficient autoubiquitination and dispersion of Sp100-containing nuclear bodies.
Brekman A, Walters MS, Tilley AE, Crystal RG
FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):688-700.
FOXJ1 prevents cilia growth inhibition by cigarette smoke in human airway epithelium in vitro.
Walters MS, De BP, Salit J, Buro-Auriemma LJ, Wilson T, Rogalski AM, Lief L, Hackett NR, Staudt MR, Tilley AE, Harvey BG, Kaner RJ, Mezey JG, Ashbridge B, Moore MA, Crystal RG
Smoking accelerates aging of the small airway epithelium. Respir Res. 2014 Sep 24; 15:94.
Smoking accelerates aging of the small airway epithelium.
Gomi K, Arbelaez V, Crystal RG, Walters MS
Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway. PLoS One. 2015; 10(2):e0116507.
Activation of NOTCH1 or NOTCH3 signaling skews human airway basal cell differentiation toward a secretory pathway.
Strulovici-Barel Y, Shaykhiev R, Salit J, Deeb RS, Krause A, Kaner RJ, Vincent TL, Agosto-Perez F, Wang G, Hollmann C, Shanmugam V, Almulla AM, Sattar H, Mahmoud M, Mezey JG, Gross SS, Staudt MR, Walters MS, Crystal RG
Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers. Am J Respir Crit Care Med. 2016 09 01; 194(5):587-95.
Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers.
Gomi K, Tang Y, Arbelaez V, Crystal RG, Walters MS
Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling. Stem Cell Rev Rep. 2017 Apr; 13(2):309-317.
Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling.
University of Oklahoma Health Sciences Center
Bodas M, Subramaniyan B, Karmouty-Quintana H, Vitiello PF, Walters MS
The emerging role of NOTCH3 receptor signalling in human lung diseases. Expert Rev Mol Med. 2022 09 02; 24:e33.
The emerging role of NOTCH3 receptor signalling in human lung diseases.
Subramaniyan B, Gurung S, Bodas M, Moore AR, Larabee JL, Reuter D, Georgescu C, Wren JD, Myers DA, Papin JF, Walters MS
The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions. Viruses. 2023 03 28; 15(4).
The Isolation and In Vitro Differentiation of Primary Fetal Baboon Tracheal Epithelial Cells for the Study of SARS-CoV-2 Host-Virus Interactions.
Subramaniyan B, Larabee JL, Bodas M, Moore AR, Burgett AWG, Papin JF, Walters MS
Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication. Am J Respir Cell Mol Biol. 2023 Sep; 69(3):367-370.
Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication.
Saxena A, Walters MS, Shieh JH, Shen LB, Gomi K, Downey RJ, Crystal RG, Moore MAS
Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells. Sci Rep. 2021 03 17; 11(1):6104.
Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells.