Kevin Brown to Humans
This is a "connection" page, showing publications Kevin Brown has written about Humans.
Connection Strength
1.185
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A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR. Am J Hum Genet. 2021 09 02; 108(9):1611-1630.
Score: 0.043
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Cell-type-specific meQTLs extend melanoma GWAS annotation beyond eQTLs and inform melanocyte gene-regulatory mechanisms. Am J Hum Genet. 2021 09 02; 108(9):1631-1646.
Score: 0.043
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Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family. Fam Cancer. 2022 07; 21(3):347-355.
Score: 0.043
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Cancer regulatory variation. Curr Opin Genet Dev. 2021 02; 66:41-49.
Score: 0.042
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Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nat Commun. 2020 06 01; 11(1):2718.
Score: 0.040
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Advancements in Composite Resin Material Enable Streamlined Direct Restoration Process. Compend Contin Educ Dent. 2019 Nov/Dec; 40(suppl 2):2-6.
Score: 0.038
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A Dynamic Cis-Regulation Pattern Underlying Epithelial Ovarian Cancer Susceptibility. Cancer Res. 2019 02 01; 79(3):439-440.
Score: 0.036
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Essential cGMP Signaling in Toxoplasma Is Initiated by a Hybrid P-Type ATPase-Guanylate Cyclase. Cell Host Microbe. 2018 12 12; 24(6):804-816.e6.
Score: 0.036
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Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. Genome Res. 2018 11; 28(11):1621-1635.
Score: 0.036
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A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF. Nat Genet. 2017 Sep; 49(9):1326-1335.
Score: 0.033
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Plasma Membrane Association by N-Acylation Governs PKG Function in Toxoplasma gondii. mBio. 2017 05 02; 8(3).
Score: 0.032
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SDHD Promoter Mutations Ablate GABP Transcription Factor Binding in Melanoma. Cancer Res. 2017 04 01; 77(7):1649-1661.
Score: 0.032
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Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii. J Biol Chem. 2016 Apr 29; 291(18):9554-65.
Score: 0.030
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A cryptic BAP1 splice mutation in a family with uveal and cutaneous melanoma, and paraganglioma. Pigment Cell Melanoma Res. 2012 Nov; 25(6):815-8.
Score: 0.024
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A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature. 2011 Nov 13; 480(7375):99-103.
Score: 0.022
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Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet. 2009 Aug; 41(8):873-5.
Score: 0.019
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Common sequence variants on 20q11.22 confer melanoma susceptibility. Nat Genet. 2008 Jul; 40(7):838-40.
Score: 0.017
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Developmental expression of Toll-like receptors-2 and -4 in preterm baboon lung. Dev Comp Immunol. 2008; 32(9):1088-98.
Score: 0.017
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Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions. Nat Genet. 2024 May; 56(5):809-818.
Score: 0.013
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Qualitative research in a cross-cultural context: Fijian experiences. Qual Health Res. 2003 Mar; 13(3):333-42.
Score: 0.012
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Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity. Am J Hum Genet. 2022 Dec 01; 109(12):2210-2229.
Score: 0.012
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Rare germline deleterious variants increase susceptibility for lung cancer. Hum Mol Genet. 2022 Oct 10; 31(20):3558-3565.
Score: 0.012
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Defining novel causal SNPs and linked phenotypes at melanoma-associated loci. Hum Mol Genet. 2022 08 25; 31(17):2845-2856.
Score: 0.012
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Functional annotation and investigation of the 10q24.33 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1. Hum Mol Genet. 2022 03 21; 31(6):863-874.
Score: 0.011
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Integrated Analysis of Coexpression and Exome Sequencing to Prioritize Susceptibility Genes for Familial Cutaneous Melanoma. J Invest Dermatol. 2022 09; 142(9):2464-2475.e5.
Score: 0.011
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A large Canadian cohort provides insights into the genetic architecture of human hair colour. Commun Biol. 2021 11 04; 4(1):1253.
Score: 0.011
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Prospective, Multicenter, Controlled Trial of Mobile Stroke Units. N Engl J Med. 2021 09 09; 385(11):971-981.
Score: 0.011
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Genomic and evolutionary classification of lung cancer in never smokers. Nat Genet. 2021 09; 53(9):1348-1359.
Score: 0.011
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Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus. Am J Hum Genet. 2021 09 02; 108(9):1590-1610.
Score: 0.011
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Developing youth capacity for community-based research: the Sarasota County demonstration project. J Public Health Manag Pract. 2001 Mar; 7(2):53-60.
Score: 0.011
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Youth and tattoos: what school health personnel should know. J Sch Health. 2000 Nov; 70(9):355-60.
Score: 0.010
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The genomic and epigenomic evolutionary history of papillary renal cell carcinomas. Nat Commun. 2020 06 18; 11(1):3096.
Score: 0.010
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Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. Nat Genet. 2020 05; 52(5):494-504.
Score: 0.010
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Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma. Mol Oncol. 2020 05; 14(5):933-950.
Score: 0.010
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Overlapping genetic architecture between Parkinson disease and melanoma. Acta Neuropathol. 2020 02; 139(2):347-364.
Score: 0.010
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Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Rep. 2019 10 15; 29(3):573-588.e7.
Score: 0.010
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Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma. Melanoma Res. 2019 10; 29(5):483-490.
Score: 0.010
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Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations. BMC Genet. 2019 07 17; 20(1):59.
Score: 0.009
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Sex specific associations in genome wide association analysis of renal cell carcinoma. Eur J Hum Genet. 2019 10; 27(10):1589-1598.
Score: 0.009
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The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. PLoS Med. 2019 01; 16(1):e1002724.
Score: 0.009
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Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma. Hum Mol Genet. 2018 12 01; 27(23):4145-4156.
Score: 0.009
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Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies. J Invest Dermatol. 2018 12; 138(12):2617-2624.
Score: 0.009
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Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor. Eur J Cancer. 2018 01; 89:90-101.
Score: 0.008
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Loci associated with skin pigmentation identified in African populations. Science. 2017 11 17; 358(6365).
Score: 0.008
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Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. Eur Urol. 2017 11; 72(5):747-754.
Score: 0.008
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Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues. Gut. 2018 03; 67(3):521-533.
Score: 0.008
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Genome-wide association study identifies multiple risk loci for renal cell carcinoma. Nat Commun. 2017 06 09; 8:15724.
Score: 0.008
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Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nat Commun. 2017 05 02; 8:15034.
Score: 0.008
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A melanin-bleaching methodology for molecular and histopathological analysis of formalin-fixed paraffin-embedded tissue. Lab Invest. 2016 10; 96(10):1116-27.
Score: 0.008
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A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis. Cell Rep. 2016 05 31; 15(9):1884-92.
Score: 0.008
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The genomic landscape of cutaneous melanoma. Pigment Cell Melanoma Res. 2016 May; 29(3):266-83.
Score: 0.007
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An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations. Proteomics. 2016 Feb; 16(3):417-26.
Score: 0.007
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Germline TERT promoter mutations are rare in familial melanoma. Fam Cancer. 2016 Jan; 15(1):139-44.
Score: 0.007
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SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res. 2015 Dec 15; 75(24):5211-8.
Score: 0.007
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Computational and human observer image quality evaluation of low dose, knowledge-based CT iterative reconstruction. Med Phys. 2015 Oct; 42(10):6098-111.
Score: 0.007
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Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma. Nat Genet. 2015 Sep; 47(9):987-995.
Score: 0.007
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Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. Cell Rep. 2015 Jun 09; 11(9):1458-73.
Score: 0.007
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Nonsense mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma. J Natl Cancer Inst. 2015 Feb; 107(2).
Score: 0.007
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A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clin Genet. 2015 Sep; 88(3):267-72.
Score: 0.007
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The effect on melanoma risk of genes previously associated with telomere length. J Natl Cancer Inst. 2014 Oct; 106(10).
Score: 0.007
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Peptidyl arginine deiminase-4 activation exacerbates kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2014 Nov 01; 307(9):F1052-62.
Score: 0.007
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Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions. Int J Cancer. 2015 Mar 15; 136(6):1351-60.
Score: 0.007
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Identification of a melanoma susceptibility locus and somatic mutation in TET2. Carcinogenesis. 2014 Sep; 35(9):2097-101.
Score: 0.007
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Assessment of PALB2 as a candidate melanoma susceptibility gene. PLoS One. 2014; 9(6):e100683.
Score: 0.007
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The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. PLoS One. 2014; 9(6):e99950.
Score: 0.007
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Whole genome profiling of spontaneous and chemically induced mutations in Toxoplasma gondii. BMC Genomics. 2014 May 10; 15:354.
Score: 0.007
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POT1 loss-of-function variants predispose to familial melanoma. Nat Genet. 2014 May; 46(5):478-481.
Score: 0.007
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Critical role of interleukin-11 in isoflurane-mediated protection against ischemic acute kidney injury in mice. Anesthesiology. 2013 Dec; 119(6):1389-401.
Score: 0.006
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A BAP1 mutation in a Danish family predisposes to uveal melanoma and other cancers. PLoS One. 2013; 8(8):e72144.
Score: 0.006
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IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI. J Am Soc Nephrol. 2013 Oct; 24(10):1558-70.
Score: 0.006
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A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet. 2013 Apr; 45(4):428-32, 432e1.
Score: 0.006
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The volatile anesthetic isoflurane induces ecto-5'-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury. Kidney Int. 2013 Jul; 84(1):90-103.
Score: 0.006
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A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2012 Sep; 303(5):F721-32.
Score: 0.006
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Array-comparative genomic hybridization reveals loss of SOCS6 is associated with poor prognosis in primary lung squamous cell carcinoma. PLoS One. 2012; 7(2):e30398.
Score: 0.006
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Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet. 2011 Dec 25; 44(2):165-9.
Score: 0.006
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Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk. J Invest Dermatol. 2012 Feb; 132(2):485-7.
Score: 0.005
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Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. Nat Genet. 2011 Oct 09; 43(11):1114-8.
Score: 0.005
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Genome-wide association study identifies three new melanoma susceptibility loci. Nat Genet. 2011 Oct 09; 43(11):1108-13.
Score: 0.005
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Genome-wide association study identifies novel loci predisposing to cutaneous melanoma. Hum Mol Genet. 2011 Dec 15; 20(24):5012-23.
Score: 0.005
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A toll-like receptor-4-interacting surfactant protein-A-derived peptide suppresses tumor necrosis factor-a release from mouse JAWS II dendritic cells. J Pharmacol Exp Ther. 2011 Mar; 336(3):672-81.
Score: 0.005
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Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet. 2010 Aug; 42(8):661-4.
Score: 0.005
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A versatile gene-based test for genome-wide association studies. Am J Hum Genet. 2010 Jul 09; 87(1):139-45.
Score: 0.005
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Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem. 2010 Aug 27; 285(35):26852-26860.
Score: 0.005
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Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One. 2010 May 28; 5(5):e10858.
Score: 0.005
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Protection against acute kidney injury via A(1) adenosine receptor-mediated Akt activation reduces liver injury after liver ischemia and reperfusion in mice. J Pharmacol Exp Ther. 2010 Jun; 333(3):736-47.
Score: 0.005
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Genome-wide association study identifies three loci associated with melanoma risk. Nat Genet. 2009 Aug; 41(8):920-5.
Score: 0.005
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Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury. Transplantation. 2009 May 27; 87(10):1478-87.
Score: 0.005
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Should all patients with duodenal adenocarcinoma be considered for aggressive surgical resection? Am J Surg. 2007 Mar; 193(3):319-24; discussion 324-5.
Score: 0.004
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Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing. Mitochondrion. 2006 Aug; 6(4):194-210.
Score: 0.004
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Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment. Cancer Res. 2005 Nov 15; 65(22):10164-9.
Score: 0.004
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Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging. 2006 Oct; 27(10):1359-71.
Score: 0.004
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An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. Cancer Res. 2005 Mar 01; 65(5):1748-54.
Score: 0.003
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Sarcoidosis: social predictors of severity at presentation. Eur Respir J. 2004 Oct; 24(4):601-8.
Score: 0.003
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Inter-platform comparability of microarrays in acute lymphoblastic leukemia. BMC Genomics. 2004 Sep 23; 5:71.
Score: 0.003
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The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma. Pediatr Neurosurg. 2003 Jul; 39(2):68-74.
Score: 0.003
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Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res. 2003 Apr 15; 63(8):1865-70.
Score: 0.003
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Occurrence of NKX3.1 C154T polymorphism in men with and without prostate cancer and studies of its effect on protein function. Cancer Res. 2002 May 01; 62(9):2654-9.
Score: 0.003
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Variation in the ESR1 and ESR2 genes and genetic susceptibility to anorexia nervosa. Mol Psychiatry. 2002; 7(1):86-9.
Score: 0.003
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No missense mutation of WKL1 in a subgroup of probands with schizophrenia. Mol Psychiatry. 2002; 7(4):419-23.
Score: 0.003
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Severe autosomal recessive rippling muscle disease. Muscle Nerve. 2001 Nov; 24(11):1542-7.
Score: 0.003
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Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet. 2001 Oct; 29(2):143-52.
Score: 0.003
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Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation. 2001 Jan 30; 103(4):485-90.
Score: 0.003
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A cholesterol-lowering diet does not produce adverse psychological effects in children: three-year results from the dietary intervention study in children. Health Psychol. 1999 Nov; 18(6):604-13.
Score: 0.002
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Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 1999 Mar 16; 256(2):299-306.
Score: 0.002
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Maternal acceptability of a dietary intervention designed to lower children's intake of saturated fat and cholesterol: the Dietary Intervention Study in Children (DISC). J Am Diet Assoc. 1998 Jan; 98(1):31-4.
Score: 0.002
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Automated detection of prevalent mutations in BRCA1 and BRCA2 genes, using a fluorogenic PCR allelic discrimination assay. Genet Test. 1997-1998; 1(3):171-80.
Score: 0.002
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A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat. Mol Cell Biol. 1990 Aug; 10(8):4192-201.
Score: 0.001