Kenneth Berlin to Structure-Activity Relationship
This is a "connection" page, showing publications Kenneth Berlin has written about Structure-Activity Relationship.
Connection Strength
0.414
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Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line. Eur J Med Chem. 2015; 96:209-17.
Score: 0.119
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Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412.
Score: 0.043
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Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780. Eur J Med Chem. 2019 May 15; 170:16-27.
Score: 0.039
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Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships. J Med Chem. 1998 Sep 10; 41(19):3753-7.
Score: 0.038
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Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis. Bioorg Med Chem. 2015 Jan 01; 23(1):203-11.
Score: 0.029
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The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking. Biochemistry. 2014 Feb 25; 53(7):1228-38.
Score: 0.028
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Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochim Biophys Acta. 2013 Jan; 1834(1):46-52.
Score: 0.025
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Development of flexible-heteroarotinoids for kidney cancer. Mol Cancer Ther. 2009 May; 8(5):1227-38.
Score: 0.020
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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrob Agents Chemother. 2009 Jul; 53(7):3065-73.
Score: 0.020
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Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells. J Med Chem. 2004 Feb 12; 47(4):999-1007.
Score: 0.014
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Novel heteroarotinoids as potential antagonists of Mycobacterium bovis BCG. J Med Chem. 2004 Feb 12; 47(4):1008-17.
Score: 0.014
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Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem. 1999 Oct 21; 42(21):4434-45.
Score: 0.010
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Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids. J Med Chem. 1999 Sep 09; 42(18):3602-14.
Score: 0.010
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Novel heteroarotinoids: synthesis and biological activity. J Med Chem. 1991 Jan; 34(1):430-9.
Score: 0.006