"Tretinoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
| Descriptor ID |
D014212
|
| MeSH Number(s) |
D02.455.326.271.665.202.495.818.500 D02.455.426.392.368.367.379.249.700.860.500 D02.455.849.131.495.818.800 D23.767.261.700.780
|
| Concept/Terms |
Tretinoin- Tretinoin
- Retinoic Acid
- Acid, Retinoic
- Vitamin A Acid
- Acid, Vitamin A
- all-trans-Retinoic Acid
- Acid, all-trans-Retinoic
- all trans Retinoic Acid
- trans-Retinoic Acid
- Acid, trans-Retinoic
- trans Retinoic Acid
|
Below are MeSH descriptors whose meaning is more general than "Tretinoin".
Below are MeSH descriptors whose meaning is more specific than "Tretinoin".
This graph shows the total number of publications written about "Tretinoin" by people in this website by year, and whether "Tretinoin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2008 | 1 | 1 | 2 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tretinoin" by people in Profiles.
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Cardiac retinoic acid levels decline in heart failure. JCI Insight. 2021 04 22; 6(8).
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Retinoic acid synthesis by a population of choroidal stromal cells. Exp Eye Res. 2020 12; 201:108252.
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Identification of Apolipoprotein A-I as a Retinoic Acid-binding Protein in the Eye. J Biol Chem. 2016 09 02; 291(36):18991-9005.
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Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye. PLoS One. 2015; 10(3):e0122008.
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History of retinoic acid receptors. Subcell Biochem. 2014; 70:1-20.
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Predictors of squamous cell carcinoma in high-risk patients in the VATTC trial. J Invest Dermatol. 2013 Jun; 133(6):1521-32.
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Predictors of basal cell carcinoma in high-risk patients in the VATTC (VA Topical Tretinoin Chemoprevention) trial. J Invest Dermatol. 2012 Nov; 132(11):2544-51.
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Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Invest Ophthalmol Vis Sci. 2011 Jul 25; 52(8):5507-14.
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RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Dev Biol. 2011 Sep 15; 357(2):347-55.
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RXR isoforms and endogenous retinoids in the fiddler crab, Uca pugilator. Comp Biochem Physiol A Mol Integr Physiol. 2008 Dec; 151(4):602-14.