Leukemia Inhibitory Factor Receptor alpha Subunit
"Leukemia Inhibitory Factor Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
| Descriptor ID |
D053680
|
| MeSH Number(s) |
D12.776.543.750.705.852.583.750 D12.776.543.750.750.400.550.250.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leukemia Inhibitory Factor Receptor alpha Subunit".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Receptors, Cytokine [D12.776.543.750.705.852]
- Receptors, OSM-LIF [D12.776.543.750.705.852.583]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.705.852.583.750]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- Receptors, Nerve Growth Factor [D12.776.543.750.750.400.550]
- Receptor, Ciliary Neurotrophic Factor [D12.776.543.750.750.400.550.250]
- Leukemia Inhibitory Factor Receptor alpha Subunit [D12.776.543.750.750.400.550.250.750]
Below are MeSH descriptors whose meaning is more specific than "Leukemia Inhibitory Factor Receptor alpha Subunit".
This graph shows the total number of publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in this website by year, and whether "Leukemia Inhibitory Factor Receptor alpha Subunit" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 2 | 2 |
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Below are the most recent publications written about "Leukemia Inhibitory Factor Receptor alpha Subunit" by people in Profiles.
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HSV-1 targets lymphatic vessels in the eye and draining lymph node of mice leading to edema in the absence of a functional type I interferon response. Am J Pathol. 2013 Oct; 183(4):1233-1242.
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Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol. 2013 Mar 15; 190(6):2807-17.
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A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. J Biol Chem. 2012 Sep 21; 287(39):32848-59.
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Loss of the type I interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection. J Virol. 2011 Feb; 85(4):1625-33.
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Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice. J Immunol. 2009 Mar 15; 182(6):3678-87.
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Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea. J Immunol. 2007 Apr 15; 178(8):5166-72.